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Berberine may interact with medicines

(1998) published in Disease Management and Clinical Outcomes found that GHK-Cu cream applied to thigh skin for 12 weeks improved collagen production in 70% of women treated, compared to 50% with vitamin C cream and 40% with retinoic acid

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But these ingredients are relatively common in supplements, so its not anything alarming

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MK-677 represents a different single-compound approach entirely