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The most common adverse effects are gastrointestinal , including nausea, vomiting, diarrhoea, and constipation

For people who fail dual agonism, triple agonism may provide the additional stimulus needed

This enhances the bioavailability and efficacy of the product

They may advise restarting at a lower dose to re-establish tolerance

Obes (Silver Spring Md) 29(12):20262034 Kolotkin RL, Gadde KM, Peterson CA, Crosby RD (2016) Health-related quality of life in two randomized controlled trials of phentermine/topiramate for obesity: what mediates improvement

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