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One of the most vulnerable brain regions to normal age-related and disease related alterations in BBB permeability is the hippocampus (Sweeney et al., 2018a

Lifestyle changes remain essential for safe, sustained weight management

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Do not allow working stock to age beyond the stability window

GLP-1 medications are FDA-approved for adults with: A BMI of 30 or higher (obesity), or A BMI of 27 or higher with at least one weight-related condition such as high blood pressure, type 2 diabetes, high cholesterol, or sleep apnea Beyond the clinical criteria, GLP-1 therapy tends to work best for people who have genuinely struggled to lose weight despite consistent effort not because of willpower, but because of underlying metabolic factors

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