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Hoertel, H

Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation

Two mortalities were recorded in the highest (5000 mg/kg) and medium (2900 mg/kg) dose groups after 24 hours, but none were recorded in the lowest (1600 mg/kg) dose group

Multiple studies have shown conflicting results on potential negative impacts on sperm numbers and quality as well as DNA fragmentation

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increased relaxin hormone levels cause joints to loosen and a loss of muscle tone in the esophagus causing increased GERD