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TNF- promotes Tumor Necrosis Factor Receptor 1 (TNFR1)-mediated internalization of GABA receptors, upregulates -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor expression, and enhances synaptic excitability, thereby triggering seizures and exacerbating emotional and cognitive dysfunction (Tripathi et al., 2024)

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Better insulin sensitivity may improve glucose control