Mistake #3: Ignoring Muscle Lean-mass preservation with protein & strength training How this shows up: Youre eating less (which is the goal), but youre also eating far less protein and skipping strength work
Tirzepatide activates both GIP and GLP-1, which is why it is called a dual agonist
SURMOUNT OSA demonstrated after 52 weeks of treatment, participants who received tirzepatide had greater likelihood of remission or improvement to mild OSA as well as reduced apnea-hypopnea index (AHI) values, hypoxic burden, and systolic blood pressure
Many patients see dramatic weight drops in a matter of months
Significant findings included up to a 30.3% average weight loss at 80 weeks a result comparable to bariatric surgery outcomes
Specifically: Monitor routinely muscle strength and function amino-acid profiles short half-life proteins emerging resilience markers (e.g., GDF-15) Mitigate proactively adequate protein intake (1.21.5 g/kg/day) resistance or mixed exercise consider adjuncts that preserve muscle mass identify early biomarker patterns of ERM These steps do not contradict the use of GLP-1RAsthey optimize it