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Compared to placebo, the 120 microg three-times-daily and 360 microg two-times-daily doses of pramlintide resulted in additional weight loss of 3.2 kg and 3.3 kg at 4 months, and 6.1 kg and 7.2 kg at 12 months, respectively

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Shaking creates aggressive mechanical forces that can break the delicate peptide bonds and denature the molecule, rendering it inactive

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