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Summary: Retatrutide is an investigational triple hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors to reduce appetite, improve glucose metabolism, and increase energy expenditure

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They are generating mice in which the protein SPHKAP can be specifically deleted from -cells, allowing them to examine how disrupting this signalling hub affects pancreatic function and GLP-1R signalling

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PLoS One Rosas HD, Chen YI, Doros G, Salat DH, Chen N, Kwong KK et al (2012) Alterations in brain transition metals in Huntington disease: an evolving and intricate story

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