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30,31 Their uptake into clinical practice has been limited partly due to safety concerns, although some mechanistic studies suggest that prolyl hydroxylase inhibitors may be protective in mouse models of DKD

The study found faster wound closure rate and a higher percentage of ulcer healing with all three GHK-Cu treatment groups over placebo, however, the 0.3% group demonstrated the fastest closure rate and highest percentage of ulcer healed compared even to the higher 3% strength treatment

Bibcode:2002PNAS...9916899M