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Safety Levels and Precautions: Current medical guidelines, supported by research in the Journal of Pregnancy , recommend avoiding GLP-1 medications during pregnancy due to potential unknown risks

The McCoy 2013 paper extended this work by introducing N- and C-terminal modifications designed to enhance metabolic stability and hydrophobicity, ultimately producing Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) as an orally active, BBB-permeable analog [2]

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Mendelian randomization analysis with multiple genetic variants using summarized data