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Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome

Setchell, K

Indications: FDA : Topical anesthesia of the upper respiratory tract (due to its combined vasoconstrictor & local anesthetic properties) Off Label : Use in Emergency Department as one ingredient in a topical anesthetic solution called TAC (containing: Tetracaine, Adrenaline & Cocaine) that is applied to a wound prior to cleaning & suturing Contraindications: Hypersensitivity to ester anesthetics Side Effects: Acute signs of systemic toxicity include can include multiple signs of both CV & CNS stimulation: tachycardia hypertension hyperthermia mydriasis seizures cardiac arrhythmias (multiple contributing variables: Na & K channel block, possible coronary vasoconstriction) Acute effects associated with cocaine abuse

10.1161/01.ATV.0000110785.96039.f6 [DOI] [PubMed] [Google Scholar] Altenhfer S, Kleikers PW, Radermacher KA et al (2012) The NOX toolbox: validating the role of NADPH oxidases in physiology and disease

Assessment of the effects of MPTP and paraquat on dopaminergic neurons and microglia in the substantia nigra pars compacta of C57BL/6 mice