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Data supporting the findings of this study are also available from the corresponding author upon requests

This coefficient is defined for infinitesimally small changes as the percentage change in the steady-state rate of the pathway divided by the percentage change in the enzyme activity causing the flux change 97

Crucially, comprehensive drug safety testing in mice indicated no significant adverse effects on myocardial, liver, or renal function markers after 30 days of treatment, suggesting a favorable safety profile [2]

In our study, we found a substantial production of H 2 O 2 , lipid peroxidation and increase in EL in the sensitive variety (VA15) of A

A 70kg human equivalent dose derived from rodent studies uses the formula: Human Equivalent Dose (mg/kg) = Animal Dose (mg/kg) (Animal Weight Human Weight)^0.33 This exponent (0.33) represents the established allometric scaling factor for small molecules with similar distribution characteristics to Dihexa

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