The study demonstrates that in the aortas of atherosclerotic mice, circular RNA circMETTL14 (11)S plays a crucial role in upregulating METTL14 expression and activates METTL14 transcription by binding to the transcription factor SOX2, thus enhancing METTL14-driven m6A methylation and stability of C-X-C chemokine receptor type 4 (CXCR4) mRNA
*Correspondence: Liyong Zhu, [email protected] These authors have contributed equally to this work This article was submitted to Molecular Medicine, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
However, under certain pathological conditions, excessive changes in organ weight due to organ congestion and oedema, hyperplasia and hypertrophy, atrophy or degeneration will occur
It describes any use in patients under 18 as off-label, requiring substantial medical justification and informed consent from both the provider and the family
S2CID 42223577
Its a deliberate strategy, not an unfocused approach
