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GLP-1 RAs have high glucose-lowering efficacy, but with variation within the drug class

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Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function

No published safety data for the combination

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In fact, human recombinant HGF (hHGF) and hHGF gene therapy (Collategene, a hHGF DNA plasmid) have been examined as a treatment option in several intractable diseases, such as amyotrophic lateral sclerosis, hepatic cirrhosis and peripheral arterial disease 11,12