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Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH (2009) Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus

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Clinical trials have shown that gastrointestinal side effects are among the most common, with nausea reported in 15-20% of patients taking semaglutide for diabetes and up to 44% of those on higher doses for weight management

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Semaglutide also led to substantial weight loss, particularly among females [189], and improved functional capacity as measured by the 6-minute walking distance test ( p for interaction = 0.19) [188]

This research was supported by the Department of Defense (W81XWH-18-1-0206), The Hartwell Foundation, the Schwartz Research Fund and the National Institute of Diabetes and Digestive and Kidney Diseasesfunded Integrated Islet Distribution Program Award Initiative (to BPC)