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This effect is currently being investigated in a phase 3 clinical trial (NCT04104321)

Lots of factors are involved including monoamine imbalances, too little neurotrophic support, brain inflammation, and changes in how neurons connect with each other

PET NPs (200 50 nm), administered orally to Kunming mice for 30 days, caused histopathological alterations and signs of fibrosis in renal tissue, whereas no such effects were observed with larger particles (700 300 nm) [142]