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Recent studies demonstrate that curcumin significantly downregulates miR-21 (oncomiR suppression) while upregulating miR-34a/b/c by two- to four-fold in colorectal cancer cells ( p = 0.002), miR-138 ( p = 0.024), and miR-16 ( p = 0.0001) in human subjects, demonstrating systemic miRNA modulation ( Resveratrol targets the miR-200 family and miR-125b-5p for epithelialmesenchymal transition (EMT) inhibition

A primary component of bile

Jama 330 (16), 15471556

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References: National Institutes of Health, Office of Dietary Supplements

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