Staying hydrated, chewing sugar-free gum, and cleaning your tongue when you brush can make a real difference
Not every patient requires the same dose or the same follow up
Clinical trials demonstrate significant weight reduction, with patients losing approximately 15% of body weight over 68 weeks with semaglutide (STEP 1 trial) and up to 21% with tirzepatide 15 mg over 72 weeks (SURMOUNT-1 trial)
The experimental data from rats suggest that the inhibitory effect of GLP-1 on gastric motor function is mediated by the afferent vagal nerve, through interaction with GLP-1Rs located in vagal afferent fibers that transmit sensory signals to the brain (161)
1,3 A 2025 systematic review in the International Journal of Dermatology confirmed that among GLP-1 receptor agonists, semaglutide and tirzepatide showed the highest reported incidence of hair loss, with telogen effluvium and androgenetic alopecia (AGA) identified as the predominant subtypes
Rather than the active compound being a peptide, it is instead a "small molecule", meaning it can withstand the harsh environment of the digestive system and is much cheaper to make and store
