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They do not replace them

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Sterile 500mg / 50mL vial (10mg / mL) 25 per tray NDC 0409-4276-02 Details and Features Concentration: 1% (10 mg/mL) Lidocaine Hydrochloride Volume: 50 mL per vial Formulation: Sterile solution for injection Packaging: Multiple-use vials, typically available in 25 per pack Preservative-Free: Often preservative-free, which is ideal for patients with hypersensitivity to preservatives Manufacturer: Pfizer Application: Administered to produce local or regional anesthesia by injection Mechanism of Action Lidocaine functions as a local anesthetic by binding to and inhibiting voltage-gated sodium channels on the nerve cell membrane

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The authors suggested that increased VIP innervation to the mucus glands was linked to increased sputum production