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Different epidemiological studies have shown a correlation between the exposure of these substances (especially in the case of pesticides) and appearance of PD [14-15, 17, 53]

Multiple cell experiments have shown that IGF-1 LR3 can improve the tight junction structure by upregulating the expression of tight junction proteins such as occludin, ZO-1, claudin-1, etc

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Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes

Astroglia respond to external, non-cell autonomous signals associated with any form of CNS pathology by undergoing complex and variable changes in their structure, molecular expression, and function

doi: 10.1038/s41577-021-00541-y 117 WetzelTJErfanSCFigueroaLDWheelerLMAnanievaEA