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GLP-1 receptor agonists are more likely to cause nausea, vomiting, dizziness, and headaches, while metformin's adverse effects are typically limited to diarrhea and abdominal pain

A yellow oval in Panel B indicates that the enzyme is affected by estradiol and/or testosterone, and therefore, its activity is different in females than males

Some patients use both routes for overlapping indications

Which peptide is better for studying appetite regulation without metabolic confounding

Semaglutide (STEP trials) achieved mean weight loss of 15.3-18.4% at higher doses

Garvey, W.T., et al., Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity