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While humans lack the nicotinamidase enzyme needed to convert NAM directly to NA, bacteria contain nicotinamidase and can deaminate NAM to NA.[2830] Gut microflora can also synthesize NAD from niacin and produce niacin equivalents from tryptophan.[3133] Niacin biosynthesis is present in the majority of the human gut microflora genomes: 63% of all investigated gut microflora genomes contained one or more NAD biosynthesis pathways.[33] Similar to other tissues, the gut also uses niacin equivalents for its needs

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Elevation of glutathione as a therapeutic strategy in Alzheimer disease

We highlight cell-typespecific roles of Nrf2 in neurons, astrocytes, and microglia, and the gene expression networks that drive CNS antioxidant and detoxification responses

Harvey J et al

Each additive targets slightly different aspects of tolerability and effectiveness