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Data synthesis and analysis All relevant baseline characteristics and study outcomes were independently extracted by AS, SF and KM, using a standardized digital extraction form, including treatment effects in patient subgroups defined by the presence or absence of CKD

Mitochondrial NADPH Generating Pathways Malic Enzymes (ME) The NADP(H)-dependent mitochondrial malic enzyme is called malic enzyme 3 and is encoded by the ME3 gene

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According to the transcripts per million reads (FPKM) method, the gene expression levels of transcript were calculated to further identify the differential expression genes (DEGs) between two groups