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Research indicates that the absorption and bioavailability of LC are maximized at "small dose" supplementation, where carrier-mediated transport dominates at low concentrations, maintaining a substantial degree of linearity (Parkhouse and McKenzie 1984)

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N Engl J Med 350(23):23352342 Kabbinavar FF et al (2005) Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer