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In previous generations of drugs, glucagon was suppressed

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Specifically, patients on exenatide had a mean improvement of 2.3 points in 48 weeks, whereas the control group had a mean decline of 1.7 points, with a difference of 4.3 points (95% CI, 7.1 to 1.6

The first 1 mg crosses the steepest portion of the GIP curve