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Molecules used in chronic weight loss studies were generated by Amgen as previously described and dosing regimens for each molecule were established by previously published pharmacokinetic and pharmacodynamic studies: mGIPR-Ab (25 mg kg 1 every 6 days) 17 , dulaglutide (0.3 mg kg 1 every 3 days) 17 and mGIPR-Ab/P1 or mGIPR-Ab/P3 (1.5 mg kg 1 every 6 days) 16