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Number of mice per group for de and gj : HF: 10, HF + Akk: 10

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Theres a reported 40-50% reduction of opioid and alcohol intoxication in people with a history of related disorders and there are phase 2 trials showing reductions in alcohol use and opioid cravings

1 Introduction Neurodegenerative diseases (NDDs) comprise a heterogeneous group of disorders characterized by the progressive loss of neurons or myelin in the brain and spinal cord, including Alzheimers disease (AD), Parkinsons disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntingtons disease (HD) (Wilson et al., 2023)