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Instead, they complement existing treatments, particularly for individuals with obesity-related OSA

When appetite diminishes, many patients instinctively eat smaller meals without adjusting macronutrient ratios

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However, they can still provide the body with energy in times of need, such as during periods of fasting or intense exercise

Model 51 , 27782786 (2011)

While these findings represent the most robust evidence to date for GLP-1 RA therapy in MC4R -deficient obesity, they derive from an exploratory analysis not pre-specified as a primary endpoint, and confirmation in prospective, dedicated trials is warranted