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What the Research Shows The approval was based on impressive results from the SURMOUNT-OSA clinical trials involving 469 adults: For people NOT using CPAP machines: Tirzepatide reduced breathing interruptions by 25 events per hour Placebo only reduced interruptions by 5 events per hour 42% achieved remission or mild symptoms after one year For people USING CPAP machines: Tirzepatide reduced breathing interruptions by 29 events per hour Placebo only reduced interruptions by 6 events per hour 50% achieved remission or mild symptoms after one year Beyond Sleep Apnea While sleep apnea research is most advanced, early evidence suggests GLP-1 medications may help with other sleep problems too: Reduced insomnia symptoms Less tossing and turning at night Improved deep sleep quality Better daytime energy levels Who Can Benefit From GLP-1 Therapy for Sleep

22, 23 Furthermore, GLP-1 receptors in this region and in the ventral tegmental area appear to be responsible for an inhibitory effect of GLP-1 on the rewarding value of food in rats

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Albiglutide was less effective in activating the GLP-1R compared to exendin-4 in an in vitro study of a BHK cell line expressing the rat GLP-1R (92)

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