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The fundamental mechanism is the activation of phase II detoxification enzymes or antioxidase controlled by Nrf2/ARE, including the expression of NAD(P)H quinone dehydrogenase 1 (NQO1), GPX, and superoxide dismutase (SOD) (Truong et al., 2014)

however, the difference in treatment duration was relatively modest (104 weeks versus 68 weeks) and unlikely to be of sufficient duration to add valuable information about the long-term safety of semaglutide

After a 4-week run-in period in which participants were treated with diet and exercise alone, those who fulfilled the randomisation criteria were randomised (1:1:1:1) using a web-based randomisation system to receive once-daily oral semaglutide 3 mg, 7 mg or 14 mg or placebo for 26 weeks (using a 4-week dose-escalation regimen for the higher doses)

( 10.1002/14651858.CD012990.pub2) [DOI] [PMC free article] [PubMed] [Google Scholar] 75.Gastrointestinal adverse events with once-weekly semaglutide: risk predictors and effect on semaglutide response Virtual Meeting|EASD

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You should also avoid sharing food and drinks with others