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These small molecule agonists increased insulin levels in primates but not rodents, which is explained by a cryo-EM structure that revealed a binding pocket requiring primate-specific tryptophan 33

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10.1152/ajpgi.00035.2013 [DOI] [PubMed] [Google Scholar] 189.Jelsing J, Vrang N, Hansen G, Raun K, Tang-Christensen M, Knudsen LB

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