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This mechanism is therapeutic for weight loss but can create transient constipation, typically resolving within 4-8 weeks as the body adjusts

Schwab et al., 1999

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5-HT may participate in the stress response by modulating central neuroendocrine networks, particularly through its influence on HPA-axis activity

Managing hormone levels with meds, a balanced diet, and anti-inflammatory supplements may help slow the shedding

However, clinical outcomes are complicated by behavioral factors, including lower adherence rates reported among women, which may obscure the true extent of sex-related efficacy differences [52]