Finally, mechanistic studies showed that the activation of nuclear factor-kappa B (NF-B) was involved in the SGNs damage caused by peroxynitrite and that GPX1 protected SGNs against peroxynitrite-induced damage, at least in part, via blocking the NF-B pathway activation
The effects of different types of antioxidants (Se, vitamin E and carotenoids) in broiler diets on the growth performance, skin pigmentation and liver and plasma antioxidant concentrations
In PCOS, ovarian tissues and GC is characterized by diminished expression of biogenesis regulatorsPGC-1, nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM) alongside increased mitochondrial DNA (mtDNA) damage and fragmentation, and ultrastructural abnormalities such as disorganized cristae, swelling, and vacuolization ( 6.3 Alleviating transzonal projection damage Transzonal projection (TZP), specialized cytoplasmic extensions connecting granulosa cells with the oocyte, emerge as critical mediators of bidirectional communication during early folliculogenesis, becoming detectable coincident with zona pellucida formation
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Firstly, activated mTOR reduces the antioxidant activity of mesangial cells in the glomerulus, promoting the production of ROS
