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Su mecanismo de accin se relaciona con la promocin de la angiognesis, la modulacin de la expresin del factor de crecimiento endotelial vascular (VEGF) y la interaccin con el eje intestino-cerebro en modelos experimentales

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Figure 5 The SURMOUNT-1 study was a clinical trial of 72 weeks performed in 2539 obese patients without T2D that were randomized in four arms with placebo or TZP at the dose of 5mg,10 mg or 15 mg (72)