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Trimethylglycine (TMG) supports methylation, liver health, and homocysteine metabolism while acting as a cellular osmolyte for stress resilience.* TMG assists homocysteine to be metabolized into methionine, resulting in the production of DMG (dimethylglycine).* The two major functions of TMG in humans are as an osmolyte to protect cells under stress and as a methyl-group donor.*

Their results demonstrated that 4-HNE could form adducts with SOX9 and lead to its ubiquitin-mediated degradation [90]

The role of erk1/2 in the development of diabetic cardiomyopathy