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doi:10.3390/nu10050541

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Severe energy deficits from extreme caloric restriction can potentially suppress reproductive function

The FDA-approved, branded versions of GLP-1 products were so popular that the brand manufacturers were not able to keep up with demand, prompting the FDA to declare a shortage for each of the semaglutide and tirzepatide products over the course of 2022

For reference, this is equal to around 7.5% of Lillys total revenues in fiscal 2024