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pre- and post-operative treatment, when requirements are increased as in fever, severe burns, increased metabolism, pregnancy, gastrointestinal disorders interfering with intake or absorption of vitamins, prolonged or wasting diseases, alcoholism and where other deficiencies exist

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Low folate status correlates with hypomethylation of CpG sites across the genome a documented feature of the aging epigenome and a driver of epigenetic clock acceleration

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