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doi: 10.21037/tcr.2020.01.62 18 UbellackerJMTasdoganARameshVShenBMitchellECMartin-SandovalMSet al

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Possible importance of leukotrienes Leukotrienes (LTs) are biologically active fatty acids derived from the oxidative metabolism of arachidonic acid through the 5-lipoxygenase pathway (Matsuyama et al

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Mechanistic interpretations in these studies typically rely on indirect evidence, such as changes in protein markers (e.g., Bax/Bcl-2 ratio, caspase activity), while direct causal validationthrough gene silencing, overexpression, or target binding assaysis rare (Xu G

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(PubMed) Caldwell KL, Pan Y, Mortensen ME, Makhmudov A, Merrill L, Moye J

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