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The mechanism of action is well-characterized and makes biological sense

31 Vitamin B12 and Hyperhomocysteinemia Vitamin B 12 deficiency is a much more common cause of hyperhomocysteinemia in developed countries than folate deficiency because of widespread fortification of food with folate

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The same studies can be located independently on PubMed using the CAS number (13441-78-4) or the compound name