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These systems typically employ temperature- or pH-sensitive biodegradable polymers that form viscoelastic depots in situ, facilitating controlled release of therapeutic agents such as GLP-1 receptor agonists while circumventing systemic toxicity [45]

doi: 10.1111/resp.12908 43 StrzelakARatajczakAAdamiecAFeleszkoW

doi: 10.1007/s40271-017-0237-9 6 DahlRE

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12, 17 This triggers the release and/or production of neurotoxic and proapoptotic compounds such as nitric oxide synthase (NOS)