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In addition to being a GLP-1 RA, Mounjaro is also a glucose-dependent insulinotropic polypeptide receptor agonist (GIP RA), and well dive a little deeper into how that improves its efficacy below.4 How we compared semaglutide and tirzepatide While these medications are extremely similar, there are four areas in which their differences are palpable enough to become points of comparison based on research studies