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Cytochrome P450 3A (CYP3A) is the primary enzyme responsible for orforglipron metabolism, with minor contributions from other CYP isoforms

It works by acting like a natural hormone called GLP-1, helping control appetite by affecting areas of the brain that manage food intake

With WeGovy we see roughly +/- 10% while with Mounjaro, its roughly +15%/-10%, compared to much larger swings with the 7-day dosing

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Novo's Wegovy obesity pill, Bloomberg reported, has passed 3m prescriptions

[5] [6] The pancreas contains GLP-1 receptors, and animal studies with GLP-1 receptor agonists have occasionally shown proliferative changes in pancreatic ductal cells and increased pancreatic mass