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Diabetic retinopathy complications have been reported primarily in patients with pre-existing diabetic retinopathy experiencing rapid glycemic improvement

Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, et al

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Several techniques reduce injection discomfort: allow the medication to reach room temperature before injecting (cold liquid can sting more), pinch the skin gently to create a slight cushion, insert the needle quickly at a 90-degree angle, and apply gentle pressure with a gauze pad for a few seconds after withdrawal