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The fixed-effect sensitivity analysis preserved the overall directional ordering, supporting the robustness of the main interpretation (Supplementary Appendix 6)

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7 Conventional Treatment Typically, silent gallstones are left untreated, but surgery may be considered for individuals deemed to have a high risk of gallbladder cancer or conditions that increase their risk of gallstone complications, such as sickle cell disease, a weakened immune system, or an upcoming weight loss surgery (Shaffer 2018