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Proper injection site selection matters because subcutaneous tissue absorption varies by location, body composition, and individual metabolic factors

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10.1001/jama.2017.7218 38 ShipleyL.GaleC.SharkeyD

In cell proliferation assays, DES(1-3) IGF-1 is approximately 10-fold more potent than native IGF-1, but IGF-1 LR3 achieves even greater sustained activation because its prolonged presence continuously stimulates the receptor