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Moreover, PHGDH upregulation confers resistance to MEK inhibitors in NRAS-mutant melanoma, whereas targeted PHGDH inhibition restores the sensitivity of resistant tumors to MAPK signaling pathway inhibitors by reducing intracellular glutathione levels and enhancing oxidative stress (89, 90)
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One statistical analysis of 13 studies of bariatric surgery in PCOS patients found a marked reduction in symptoms accompanied by an over 50% loss of body weight
In August 2025, Eli Lilly (US) announced a collaboration with a leading technology firm to integrate artificial intelligence into its drug development processes
EndMT: endothelial-mesenchymal transition
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