Mild fatigue during dose escalation is common
Typical trial exclusion criteria for retatrutide studies, consistent with those applied to similar investigational and licensed medicines in this class, have included: pregnancy or breastfeeding (with active contraception requirements during participation)
Clinical Rationale for Early AOM Intervention Traditional obesity management often follows a fixed-duration behavioral therapy (BT) approach before considering medication, yet mounting evidence suggests this may not be optimal for many patients
These spots may not absorb medication the same way as surrounding tissue, and they can be more sensitive or harder to inject comfortably
It has already moved into larger, late-stage trials
If results plateau despite adherence, discuss dose optimization or adjunctive strategies with your healthcare provider