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Other local factors expressed by hypertrophic chondrocytes that promote angiogenesis include FGFs [251253] and matrix metalloproteinase 9 (MMP-9) [81,247,250,254,255]

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Hamilton Depression Rating Scale (HDRS), 23 Beck Depression Inventory (BDI), 24 and Montgomerysberg Depression Rating Scale (MADRS) 25 as standardized mean differences (SMDs) and their corresponding 95% CI at end-of-treatment (negative values favor ALC) using random-effects (REML) models