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Even before the 1994 Centers for Disease Control and Prevention definition of ME/CFS, Kent-Braun et al

Importantly, this study also demonstrates limited impacts of metformin treatment on the metabolic profile of non-cancer rectal tissue, supporting its potential utility as a radiosensitising agent in the management of rectal cancer

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Converts fat to energy providing support for endurance exercise (aerobic) and during recovery from high-intensity activities such as weightlifting and sprinting (anaerobic)