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Unlike phosphodiesterase-5 (PDE5) inhibitors such as sildenafil, PT-141 works centrally in the brain rather than directly on penile blood vessels

it has also been reported to promote angiogenesis, down-regulate inflammatory cytokines and NF-B signaling, and reduce apoptosis and fibrosis in injury models

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Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration

Once the key pathways are covered (usually with 2-3 peptides), additional compounds compete for the same receptors or introduce new side effect vectors